Alan List, MD and Guillermo Garcia-Manero, MD
In this episode, “Advances in MDS Biology,” Alan List, MD and Guillermo Garcia-Manero, MD highlight scientific developments in in myelodysplastic syndromes (MDS).
Mounting evidence indicates a direct role for chronic innate immune response dysregulation in the pathogenesis of MDS. ASC specks, a component of inflammasome-directed cell death, represent a sensitive and specific candidate plasma biomarker of medullary cell death and ineffective hematopoiesis in patients with MDS. Age-related clonal hematopoiesis is another transformative concept with exciting implications for practice.